A Histopathologic Survey Of Prostate Disease In The Sultanate Of Oman

摘要

The aim of this retrospective study is to determine the pattern of prostate diseases in the Sultanate of Oman by analyzing prostate biopsies received at the Department of Pathology, The Royal Hospital, Muscat, Sultanate of Oman during a 5 year period from July 1999 to June 2004. The results are compared with data from the Middle East and from the West.During the 5 year period of this study 1163 patients had prostate biopsies and of these 10.9% (n= 127) were malignant, 0.6% (n=7) showed high grade prostate intraepithelial neoplasia and the remaining 88.5% (n=1029) were nodular hyperplasia.The majority (125 cases) of the malignancies were carcinomas, with two non Hodgkin lymphomas and most of the carcinomas (65.6%) were poorly differentiated with Gleason score 7 to 10.The highest incidence of malignancies and hyperplasia occurred between 61 and 70 years of age. Introduction In the Sultanate of Oman cancer of the prostate is the fourth commonest cancer among Omani males with an incidence of 29 in 2003, according to a publication of the Ministry of Health (1).There has not been any study done in Oman with a view to compare the statistics with other areas especially the Middle East; hence we have attempted to survey the pattern of prostate disease based on an analysis of histopathological specimens, with a review of literature. Materials And Methods The Royal Hospital is a tertiary care teaching hospital of the Ministry of Health and as it receives specimens from all over the country, the data pertains to the entire population.Prostate specimens from 1163 Omani patients were received in the Department of Pathology between July 1st 1999 and June 30th 2004. These include transurethral prostate resections, needle biopsies and suprapubic prostatectomy specimens. All lesions were classified as benign or malignant with the latter further categorized into the type of malignancy. As all clinically suspected prostatitis are not biopsied this entity is not included in the study. Carcinomas were graded and scored according to the Gleason system. The age distribution was also noted. The literature was searched for comparative data. Results A total of 1163 patients with prostate biopsies during the 5 year period from July 1st 1999 to June 30th 2004 were analyzed. Of these 1029 (88.5%) were benign and showed hyperplasia.Malignant lesions were seen in 127(10%) patients with 125 adenocarcinomas and 2 cases of non Hodgkin lymphoma of diffuse large B cell type. Seven biopsies (0.6%) revealed high grade prostate intraepithelial neoplasia. The age distribution for benign and malignant prostate lesions is shown in Table 1.