Aldosterone has been linked to the deleterious cardiovascular Chronically elevated fatty acids contribute to insulin resistance through poorly defined mechanisms. Endoplasmic reticulum (ER) stress and the subsequent unfolded protein response (UPR) have been implicated in lipid-induced insulin resistance. However, the UPR is also a fundamental mechanism required for cell adapta- tion and survival. We aimed to distinguish the adaptive and del- eterious effects of lipid-induced ER stress on hepatic insulin ac- tion. Exposure of human hepatoma HepG2 cells or mouse primary hepatocytes to the saturated fatty acid palmitate en-.
展开▼
