Age-related depletion of estrogens and androgens is asso- ciated with an increase in Alzheimer's disease (AD) brain pa- thology and diminished cognitive function. Here we investi- gated AD-associated molecular and cellular changes in brains of aged hypogonadal (hpg) male and female mice. hpg Mice have a spontaneous, inactivating genetic mutation in the GnBFH gene resulting in life-long deficiency of gonadotropins and gonadal sex hormones. Western blot analysis revealed low levels of amyloid precursor protein and high levels of.
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