Management of Adolescents with Polycystic Ovary Syndrome

摘要

PCOS) isa disorder of metabolic P as well as reproductive function; common (although not universal) comorbidities include insulin resistance, hyperinsu- linemia, hypoadiponectinemia, dyslipidemia, hepatic steatosis, carotid intimal medial thickening, impaired glucose toler- ance, and a predisposition to type 2 diabetes and cardiovas- cular disease (1, 2). Studies in monozygotic and dizygotic twins (3) suggest that PCOS emerges from the interaction of genetic and environmental factors; the latter may in- clude intrauterine as well as nutritional determinants (1). High-risk groups include low birth weight girls who de- velop precocious adrenarche and children with family his- tories of PCOS (4).