Pegylated Long-Acting Human Growth Hormone Possesses a Promising Once-Weekly Treatment Profile, and Multiple Dosing Is Well Tolerated in Adult Patients with Growth Hormone Deficiency

Esben S?ndergaard; Marianne Klose; Mette Hansen; Birgit Sehested Hansen; Marianne Andersen; Ulla Feldt-Rasmussen; Torben Laursen; Michael H?jby Rasmussen; Jens Sandahl Christiansen

首页> 外文期刊>The journal of clinical endocrinology and metabolism >Pegylated Long-Acting Human Growth Hormone Possesses a Promising Once-Weekly Treatment Profile, and Multiple Dosing Is Well Tolerated in Adult Patients with Growth Hormone Deficiency

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Pegylated Long-Acting Human Growth Hormone Possesses a Promising Once-Weekly Treatment Profile, and Multiple Dosing Is Well Tolerated in Adult Patients with Growth Hormone Deficiency

机译：聚乙二醇化长效人类生长激素具有令人鼓舞的每周一次治疗概况，对成年生长激素缺乏症患者的多剂量耐受性良好

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Background:Recombinant human GH (rhGH) replacement therapy in children and adults currently requires daily sc injections for several years or lifelong, which may be both inconvenient and distressing for patients. NNC126-0083 is a pegylated rhGH developed for once-weekly administration.

机译：背景：儿童和成人的重组人GH（rhGH）替代疗法目前需要每天皮下注射数年或终身，这可能给患者带来不便和困扰。 NNC126-0083是开发用于每周一次给药的聚乙二醇化rhGH。

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《The journal of clinical endocrinology and metabolism》 |2011年第3期|共8页
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Esben S?ndergaard; Marianne Klose; Mette Hansen; Birgit Sehested Hansen; Marianne Andersen; Ulla Feldt-Rasmussen; Torben Laursen; Michael H?jby Rasmussen; Jens Sandahl Christiansen;
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1. Pegylated Long-Acting Human Growth Hormone Is Well-Tolerated in Healthy Subjects and Possesses a Potential Once-Weekly Pharmacokinetic and Pharmacodynamic Treatment Profile [J] . Michael H?jby Rasmussen, Britta V. Bysted, Thomas W. Anderson, The journal of clinical endocrinology and metabolism . 2010,第7期

机译：聚乙二醇化长效人类生长激素在健康受试者中耐受性良好，并且具有潜在的每周一次药代动力学和药效学治疗概况
2. Pegylated Long-Acting Human Growth Hormone Is Well-Tolerated in Healthy Subjects and Possesses a Potential Once-Weekly Pharmacokinetic and Pharmacodynamic Treatment Profile [J] . Michael H?jby Rasmussen, Britta V. Bysted, Thomas W. Anderson, The journal of clinical endocrinology and metabolism . 2010,第7期

机译：聚乙二醇化长效人类生长激素在健康受试者中耐受性良好，并且具有潜在的每周一次药代动力学和药效学治疗概况
3. Multiple doses of pegylated long-acting growth hormone are well tolerated in healthy male volunteers and possess a potential once-weekly treatment profile. [J] . Rasmussen MH, Jensen L, Anderson TW, Clinical Endocrinology . 2010,第6期

机译：在健康的男性志愿者中，多剂量的聚乙二醇化长效生长激素具有良好的耐受性，并具有每周一次的治疗潜力。
4. COMPARISON OF GROWTH HORMONE SECRETION PATTERNS IN CHILDREN WITH AND WITHOUT HORMONAL DEFICIENCY [C] . R.C. Hermida, L. Garcfa, D.E. Ayala 1995 IEEE engineering in medicine and biology 17th annual conference and 21st Canadian medical and biological engineering conference . 1997

机译：有和没有荷尔蒙缺乏症的儿童生长激素分泌型态的比较
5. Plasticity of pituitary hormone secretion, expression and cell numbers within the anterior pituitary glands of human growth hormone-releasing hormone transgenic mice: Focus on galanin, growth hormone, and prolactin. [D] . Moore, Joseph Patrick, Jr. 1997

机译：人类生长激素释放激素转基因小鼠的垂体前叶垂体激素分泌，表达和细胞数量的可塑性：专注于甘丙肽，生长激素和催乳激素。
6. Reversible Albumin-Binding GH Possesses a Potential Once-Weekly Treatment Profile in Adult Growth Hormone Deficiency [O] . Michael Højby Rasmussen, Jurgita Janukonyté, Marianne Klose, -1

机译：结合白蛋白的可逆生长激素在成人生长激素缺乏症中具有潜在的每周治疗方案
7. Pegylated Long-Acting Human Growth Hormone Possesses a Promising Once-Weekly Treatment Profile, and Multiple Dosing Is Well Tolerated in Adult Patients with Growth Hormone Deficiency [O] . Søndergaard, Esben, Klose, Marianne Christina, Hansen, Mette, 2011

机译：聚乙二醇化长效人类生长激素具有令人鼓舞的每周一次治疗概况，对成年生长激素缺乏症患者的多剂量耐受性良好

Pegylated Long-Acting Human Growth Hormone Possesses a Promising Once-Weekly Treatment Profile, and Multiple Dosing Is Well Tolerated in Adult Patients with Growth Hormone Deficiency

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