Lack of Action of Exogenously Administered T3 on the Fetal Rat Brain Despite Expression of the Monocarboxylate Transporter 8

摘要

E2 replacement in vivo. Subsequent investigations in isolated cardiac myocytes found that in vitro E, activated NF-?B, HSF-1, and increased HSP 72 expression in adult but not old rats. In response to hypoxia/reoxygenation, myocytes from adult, but not old, rats had increased HSP 72 expression. In addition, ex- pression of the inflammatory cytokines TNF-a and IL-1, as well as oxidative stress, were increased in myocytes from old ovari- ectomized rats; only the change in cytokine expression could be attenuated by in vivo E, replacement. This study demonstrates that while aging in female rats led to a loss of the cardioprotective HSP response, E; retains its protective cellular properties.