Recombinant Insulin-Like Growth Factor (IGF)-I Treatment in Short Children with Low IGF-I Levels: First-Year Results from a Randomized Clinical Trial

摘要

Context: Short stature in children may be associated with low IGF-I despite normal stimulated GH levels and without other causes.Objective: Our objective was to assess the safety and efficacy of recombinant human IGF-I (rhIGF-I) in short children with low IGF-I levels.Design: This was a 1-yr, randomized, open-label trial (MS301).Setting: The study was conducted at 30 U.S. pediatric endocrinology clinics.Subjects: A total of 136 short, prepubertal subjects with low IGF-I (height and IGF-I sd scores