Objective: Rheumatoid Arthritis (RA) may be associated with vasculopathy, peripheral, autonomic and entrapment neuropathy. In this study, carpal tunnel syndrome (CTS) in patients with RA was investigated.Subjects And Method: 40 adult patients (totally eighty hands) with RA according to the revised criteria of American College of Rheumatology and 20 healthy volunteers (totally forty hands) for control group were included into the study. Nerve conduction velocity was performed to the both groups. Results: Carpal tunnel syndrome (usually in sensorimotor axonopathy form) was determined in 20 hands (25%) of the patients with RA but it was not found in the control group. The three hands had minimal CTS (3.75%), five hands had mild CTS (6.25%), five hands had moderate CTS (6.25%) and the rest had severe CTS (8.75%), (p<0.005). Conclusions: In this study, the prevalence of CTS in patients with RA may be high. We consider that treatment of CTS by medical and/or surgery methods in RA patients will decrease complaints and increase life quality. Therefore, we recommend that an electroneurophysiologic examination should be performed in all patients with RA as routine diagnostic procedure. Introduction Rheumatoid Arthritis (RA) is a systemic inflammatory disease of unknown etiology characterized by the manner in which it involves the joints. RA is also associated with vasculopathy, peripheral, autonomic and entrapment neuropathy resulting in distal sensory, combined sensory and sensorimotor neuropathy (1, 2, 3, 4). Carpal tunnel syndrome (CTS) is the most common form of entrapment neuropathies, and is the prototypical injury of the median nerve at the wrist is either an acute or chronic compressive lesion. It is usually diagnosed by the electrodiagnostic studies and clinical findings are variable and include symptoms of burning pain, tingling, numbness, and weakness or atrophy in the hands of the patients (5). Tenosynovial proliferation of the flexor tendons which increases pressure in the carpal tunnel causes to CTS in patients with RA (4). It is often difficult to diagnose early stage of CTS in the examination of the peripheral neuromuscular system due to similar symptoms resulting from pain in the joints, and limitations of movement (6). However, electrodiagnostic studies clearly show the existence of subclinical neuropathies (7).The aim of this study is to indicate the importance of CTS in RA patients and to determine frequency of it by means of electrodiagnostic studies. It is well-known that CTS could be treated by medical and/or surgery methods. Therefore, complaints from CTS will decrease and life quality of patients with RA will increase. Subjects And Methods SubjectsThis study was carried out in the Departments of Neurology and Physical Medicine-Rehabilitation at University of Dicle in Diyarbakir, between March 2002 and January 2003. Eighty hands of 40 adult patients with RA (34 female, 6 male, aged 20-70 year, mean 45.9±10.90 yr) were included into the study. Forty hands of 20 healthy volunteers (12 female, 8 male, aged 30-65 mean 43.8 ±5.66 yr) who had normal neurological examination were accepted as control group. RA was defined according to revised criteria of the American College of Rheumatology (8). The mean duration of RA in these patients was 5.6 years (± 5.8 month). The preliminary criteria for clinical remission in RA were used to evaluate the remission of the patients and the results showed five of them were in the remission (9). The general activities of the other patients with RA were relatively well controlled by the oral administration of non-steroidal anti-inflammatory drugs, disease modifying anti-rheumatoid drugs, or corticosteroids. Patients with diabetes mellitus (fasting serum glucose level ≥ 126 mg/dL), hepatic, renal disorders, cervical neuropathy, chronic abuse of drugs and other peripheral neuropathies were excluded. MethodsNerve conduction studiesThe electrodiagnosis protocol recommended by American Assoc
展开▼
