A Long-Term Survival Of Small Cell Lung Cancer Developed Diffuse Large B-Cell Lymphoma

摘要

We are reporting a rare case of a patient with a long-term survival of a small cell lung cancer (SCLC) who later developed a diffuse large B-cell lymphoma in the left neck. The patient was a smoker, and at age 50, was diagnosed with limited-stage small cell lung cancer. He was treated with chemotherapy and concurrent radiation therapy, and received prophylactic cranial irradiation resulting in a complete remission. Now, eight years later, he has developed an 8 cm mass at the supraclavicular lymph node. Biopsy confirmed a diffuse large B-cell lymphoma. His bone marrow was not involved. With treatment of intense chemotherapy and involved field radiation of the left neck, he is now in complete remission. Long-term survivors of SCLC may develop a second cancer including high-grade lymphoma. Thus, closely following up patients with SCLC is essential. Introduction SCLC is the fifth most common cause of cancer death in the United States; each year, almost 40,000 new cases are diagnosed.1-3 At the diagnosis, approximately 30% of patients with SCLC will have tumor confined to the hemithorax of origin, the mediastinum, or the supraclavicular lymph nodes. These patients are designated as having limited-stage SCLC. Patients with tumors have spread beyond the supraclavicular areas are stated to have extensive-stage SCLC. The majority of these patients will die of the disease.1-3 With intensive chemotherapy and radiation therapy, long-term survivors with SCLC are increasing.1-4 However, developing a second cancer is increasing including mainly non-small cell lung cancer, but rarely is a lymphoma.