Objectives A novel analysis was undertaken to select a significant ultrasonographic parameter (USP) for classifying fetuses to support artificial neural network (ANN), and thus to enhance the accuracy of fetal weight estimation. Methods In total, 2127 singletons were examined by prenatal ultrasound within 3 days before delivery. First, correlation analysis was used to determine a significant USP for fetal grouping. Second, K -means algorithm was utilized for fetal size classification based on the selected USP. Finally, stepwise regression analysis was used to examine input parameters of the ANN model. Results The estimated fetal weight (EFW) of the new model showed mean absolute percent error (MAPE) of 5.26?±?4.14% and mean absolute error (MAE) of 157.91?±?119.90?g. Comparison of EFW accuracy showed that the new model significantly outperformed the commonly-used EFW formulas (all p < 0.05). Conclusion We proved the importance of choosing a specific grouping parameter for ANN to improve EFW accuracy.
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