Poorly soluble drugs have low bioavailability, representing a major challenge for the pharmaceutical industry. Processing drugs into the nanosized range changes their physical properties, and these are being used in pharmaceutics to develop innovative formulations known as Nanocrystals. Use of nanocrystals to overcome the problem of low bioavailability, and their production using different techniques such as microfluidization or high pressure homogenization, was reviewed in this paper. Examples of drugs, cosmetics and nutraceutical ingredients were also discussed. These technologies are well established in the pharmaceutical industry and are approved by the Food and Drug Administration.
展开▼
机译：难溶性药物的生物利用度低，这是制药行业的主要挑战。将药物加工到纳米范围会改变其物理性质，这些药物已被用于制药领域，以开发出称为纳米晶体的创新配方。本文综述了使用纳米晶体克服生物利用度低的问题，并使用微流化或高压均质化等不同技术生产纳米晶体。还讨论了药物，化妆品和营养成分的例子。这些技术已在制药行业中确立，并获得了美国食品和药物管理局（Food and Drug Administration）的批准。
展开▼
