PDW and RDW are new parameters for bipolar episodes and unipolar depression

摘要

INTRODUCTION: Bipolar disorder (BD) and unipolar depression (UD) are complex andmultifactorial mental disorders characterized by mood swings, disability, and impaired qualityof life. In the present study, we researched the roles of inflammatory cells and their value asinflammation markers in BD and UD.OBJECTIVE: Sixty-nine manic, 60 euthymic, and 70 UD patients and 60 sex-matched healthyvolunteers (control group) were retrospectively analysed. Platelet (PLT), platelet distributionwidth (PDW), and red cell distribution width (RDW) levels were measured in four groups. Theaim of this study was to evaluate PLT, PDW, and RDW levels patient with UD and twodifferent phases of BD: euthymic and manic.RESULTS: In our study, 199 patients and 60 controls were included. There were no differencesbetween the patients and the healthy control group participants in terms of age and sex. Thebipolar episodes and the UD patient group were statistically significantly different from thehealthy controls in terms of PLT, PDW, and RDW.CONCLUSION: Our study is the first in the literature to compare blood PLT, PDW, and RDWlevels in bipolar episodes, UD patients, and healthy control groups. We believe that the levelsof PLT, PDW, and RDW can be used as novel markers of bipolar episodes and UD. Moredetailed and larger prospective clinical studies are required to confirm these findings.