Vitamin D Levels in Subjects with Prostate Cancer Compared to Age-Matched Controls

摘要

Prostate cancer (PCa) is the second most common cancer in men worldwide and the second leading cause of cancer deaths in men in the United States. Vitamin D is considered to have anticancer properties, currently thought to work mainly through its nuclear receptor or vitamin D receptor. In this retrospective study, we compared vitamin D levels in subjects with PCa with those of age-matched men without PCa. Study subjects included 479 in each group with a mean age of 73 and a mean creatinine of 1.05 and 1.15. Levels of 25 (OH) vitamin D were28.4±0.54and28.05±0.62in subjects with and without PCa. Levels of 1,25 (OH) vitamin D were47.2±6.8and47.1±7.11in subjects with and without PCa. In contrast to other studies, we did not find a significant difference in vitamin D levels. Among prostate cancer patients, vitamin D levels correlated positively with age (r=0.12,P<0.02), and were negatively associated with BMI (r=−0.13,P=0.003), glucose (r=−0.12,P<0.007), HbA1C (r=−0.16,P=0.001), and PTH (r=−0.21;P<0.0001). The data do not show the causal effect of vitamin D levels on PCa.