Mechanism of actions of Oncocin, a proline-rich antimicrobial peptide, in early elongation revealed by single-molecule FRET

摘要

Proline-rich antimicrobial peptides (PrAMPs) are a class ofantimicrobial peptides containing a high content of prolineresidues. PrAMPs selectively target Gram-negative bacteriathrough special transporters such as SmbA to enter cytoplasm(Mattiuzzo et al., 2007). On the other hand, PrAMPspresent a low toxicity to mammalian cells, because theycannot effectively penetrate the mammalian cellular membrane(Hansen et al., 2012) or they are internalized throughan endocytotic process to minimize interaction with cytosolicribosomes (Tomasinsig et al., 2006). Therefore, PrAMPs arepromising candidates to treat infections and to deliver drugs(Schmidt et al., 2016).