The Sysmex CS-5100 coagulation analyzer offers comparable analytical performance and excellent throughput capabilities

摘要

Objectives This study compared the new high-volume blood coagulation analyzer Sysmex CS-5100 System? (Siemens Healthcare Diagnostics, Erlangen, Germany) to the mid-volume blood coagulation analyzer Sysmex CS-2000 i System? (Siemens) for analytical performance. Additionally, the operational performance of the Sysmex CS-5100 System was compared with the blood coagulation analyzer ACL TOP 700 (Instrumentation Laboratory, Werfen Group, Kirchheim bei Munchen, Germany). Materials and methods We compared the Sysmex CS-5100 to the Sysmex CS-2000 i and the ACL TOP analyzer for routine coagulation, chromogenic and immunological assays. Imprecision studies were performed for the Sysmex CS-5100 and Sysmex CS-2000 i systems. A throughput and STAT analysis comparison of the CS-5100 and the ACL TOP was performed. A stress test was performed to characterize the robustness and the error rate of the CS-5100. We also performed correlation analysis between the CS-5100 and the CS-2000 i or the ACL TOP in the measurement of patients’ samples. Results The inter-assay precision using the CS systems was impressive (inter-assay CV generally 3.5%) and the correlation between the two Sysmex analyzers was excellent. In the throughput study, the CS-5100 completed the measurement of 100 samples (210 results) in less than 49 min. Conclusions Our results demonstrated that the CS-5100 is a robust high-throughput analyzer, well-suited for coagulation laboratories. Highlights ? We show a comparison between the CS-5100, CS-2000i and ACL TOP 700. ? CS-5100 is a high-volume coagulation analyzer with excellent inter-assay precision. ? The system has a considerable high throughput and a good software usability. ? The software was simple, intuitive to use and offers various monitoring possibilities.