Notable effect of bromocriptine monotherapy on macroprolactinoma with self-limited cerebrospinal fluid rhinorrhea

摘要

2 episodes of unilateral (right) intermittent cere?brospinal fluid (CSF) rhinorrhea lasting about 1month each after 1 month and 2.5 years of bro?mocriptine administration, respectively. Afterbeing informed of the risks, the patient still re?fused the repair of CSF leakage for economic rea?sons. Therefore, he was treated with antibiotics(oral cefdinir, 0.1 g, 3 times daily), in addition tothe recommendation of bed rest and cleaning ofthe nasal cavities. The CSF rhinorrhea stoppedspontaneously. Magnetic resonance imaging re?vealed that the maximum diameter of the pitu?itary adenoma reduced to 2.4 cm (FIGURE 1D–1F) af?ter 3 years of medication. Moreover, the prolactinlevel normalized. The final dose of bromocriptinewas 6.25 mg/d, and CSF rhinorrhea did not recurduring subsequent follow?up visits.