Is the Current Management of Severe Sepsis and Septic Shock Really Evidence Based?

摘要

Evidence-based medicine (EBM), a process of accurately assessing and integrating the weight carried by various levels of available evidence, (e.g., randomized controlled trials [RCTs], case-control studies, case series, and expert opinion) has become the cornerstone of good medical practice. The RCT is considered the “gold-standard” of EBM, but, while the RCT may indeed be the most statistically unbiased method of assessing an intervention, it can also have limitations and must be correctly interpreted, aided by other forms of evidence.