Exercise training improves vascular function in adolescents with type 2 diabetes

摘要

The impact of exercise training on vascular health in adolescents with type 2 diabetes has not been previously studied. We hypothesized that exercise training would improve micro?￠???? and macrovascular health in adolescents with type 2 diabetes. Thirteen adolescents (13?￠????21????years, 10F) with type 2 diabetes were recruited from Princess Margaret Hospital. Participants were randomized to receive either an exercise program along with standard clinical care ( n ????=????8) or standard care alone ( n ????=????5). Those in the intervention group received 12????weeks of gym?￠????based, personalized, and supervised exercise training. Those in the control group were instructed to maintain usual activity levels. Assessments were conducted at baseline and following week 12. The exercise group was also studied 12????weeks following the conclusion of their program. Assessments consisted of conduit artery endothelial function (flow?￠????mediated dilation, FMD) and microvascular function (cutaneous laser Doppler). Secondary outcomes included body composition (dual?￠????energy X?￠????ray absorptiometry, DXA), glycemic control (whole body insulin sensitivity, M) assessed using the euglycemic?￠????hyperinsulinemic clamp protocol, cardiorespiratory fitness ( ), and muscular strength (1RM). Exercise training increased FMD ( P???? < ???? 0.05), microvascular function ( P???? < ???? 0.05), total lean mass ( P???? < ???? 0.05), and muscle strength ( P????