EVALUATION OF THE CELL CYTOTOXICITY OF β-TRICALCIUM PHOSPHATE DOPED WITH VANADIUM IONS

摘要

Tricalcium phosphate doped with a small amount of both V(III) and V(V) ions (V-β-TCPV) was successfully prepared using a solid-state reaction, and its in vitro cell cytotoxicity was investigated using V79 cells. We found that the V(III) ion was substituted for a Ca ion at the Ca(5) site located in the β-Ca_(3)(PO_(4))_(2) (β-TCP) crystal structure and that the V(V) ion was substituted for a P ion in the PO_(4) group of the β-TCP crystal structure. The cell cytotoxicity of the V-β-TCPVs increased gradually with increasing amounts of vanadium ion doping. The β-TCP doped with 1.0 mol% vanadium ions showed low toxicity. V-β-TCPVs doped with a small amount of vanadium ions are expected to be significant new implant biomaterials.