Development and validation of UV-visible spectrophotometric baseline manipulation methodology for simultaneous analysis of drotraverine and etoricoxib in pharmaceutical dosage forms

摘要

Introduction: A simple, economical, precise, and accurate new UV spectrophotometricbaseline manipulation methodology for simultaneous determination of drotaverine(DRT) and etoricoxib (ETR) in a combined tablet dosage form has been developed.Materials and Methods:....................................................................................................................spectroscopy where the amplitudes at 274 and 351 nm were selected to determine ETRand DRT, respectively, in combined formulation and methanol was used as solvent...........................................................................................................................................................................................................................Results: The results of analysis have been validated statistically........ .................. ................ .................. ........ .................. ........ ................................ ...... ........ ..................method which were carried out by following the ICH guidelines. Conclusion: It has beenconcluded that a new simple and accurate UV spectrophotometric baseline manipulationmethod was developed for simultaneous determination of drotaverine and ETR ina combined tablet dosage form has been developed.