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Zika virus infection in a pediatric patient with acute gastrointestinal involvement

机译:小儿急性胃肠道感染的寨卡病毒感染

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Zika virus (ZIKV) is a mosquito-borne flavivirus, which has been related to severe neurological complications in neonates. However, many clinical aspects of the infection remain unclear, especially in pediatric patients. In this case report we describe the uncommon presentation of ZIKV infection in a pediatric patient with acute gastrointestinal involvement hospitalized in a Brazilian Emergency Unit. Dengue hemorrhagic fever was initially suspected, however, the molecular result for Dengue was negative. Molecular testing for other arboviruses (ZIKV and Chikungunya), revealed positive for ZIKV RNA result in both blood and saliva. The ZIKV load in saliva (6.947 copies/mL) was higher than the vetected ZIKV RNA in plasma (1.945 copies/mL). Additionally, the performed abdominal ultrasound revealed mesenteric lymphadenitis without abdominal retention of fluids. The presentation of this case demonstrates that ZIKV can be involved in a broader range of clinical conditions than currently assumed, including pediatric emergencies, especially in regions with extensive ZIKV outbreaks.
机译:Zika病毒(ZIKV)是一种蚊子传播的黄病毒,与新生儿的严重神经系统并发症有关。但是,感染的许多临床方面仍不清楚,尤其是在小儿患者中。在此病例报告中,我们描述了在巴西急诊科住院的急性胃肠受累儿科患者中ZIKV感染的罕见表现。最初怀疑是登革出血热,但是登革热的分子结果为阴性。对其他虫媒病毒(ZIKV和基孔肯雅热)的分子测试显示,ZIKV RNA在血液和唾液中均呈阳性。唾液中的ZIKV载量(6.947拷贝/ mL)高于血浆中经检验的ZIKV RNA(1.945拷贝/ mL)。此外,进行的腹部超声检查显示肠系膜淋巴结炎没有腹水滞留。该病例的报道表明,与目前的设想相比,ZIKV可能涉及更广泛的临床疾病,包括小儿急症,尤其是在ZIKV暴发广泛的地区。

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