Anti-Zika virus IgA as putative indicator of acute infection in anti-Zika virus IgM-negative patients

摘要

Purpose: Especially in secondary flavivirus infections specific IgM - the classical marker of acute infection – is often found at low titer, sometimes being even undetectable, while synthesis of specific IgG is rapidly stimulated. Shortly after infection, the IgG titer then levels off at moderate concentration, indistinguishable from IgG titers in convalescent infections. Similar situations have also been observed in patients with Zika virus (ZIKV) infections, recently, making it difficult to discriminate between an acute secondary and a past infection.