Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in rat

Clémence Disdier; Jér?me Devoy; Anne Cosnefroy; Monique Chalansonnet; Nathalie Herlin-Boime; Emilie Brun; Amie Lund; Alo?se Mabondzo

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Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in rat

机译：静脉注射二氧化钛纳米颗粒的组织生物分布显示大鼠血脑屏障清除和脑部炎症

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Background Notwithstanding increasing knowledge of titanium dioxide nanoparticles (TiO₂ NPs) passing through biological barriers, their biodistribution to the central nervous system (CNS) and potential effects on blood-brain barrier (BBB) physiology remain poorly characterized.

机译：背景技术尽管对二氧化钛纳米颗粒（TiO _{2 NPs）通过生物屏障的了解有所增加，但它们在中枢神经系统（CNS）中的生物分布以及对血脑屏障（BBB）生理学的潜在影响仍然不明确。。}

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《Particle Fibre Toxicology》 |2015年第1期|共页
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Clémence Disdier; Jér?me Devoy; Anne Cosnefroy; Monique Chalansonnet; Nathalie Herlin-Boime; Emilie Brun; Amie Lund; Alo?se Mabondzo;
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中图分类毒物学（毒理学）;
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1. Tissue distribution and clearance of intravenously administered titanium dioxide (TiO2) nanoparticles [J] . Shinohara Naohide, Danno Nobuko, Ichinose Takayuki, Nanotoxicology . 2014,第1a8期

机译：静脉注射二氧化钛（TiO2）纳米颗粒的组织分布和清除
2. Blood-brain barrier opening with alkylglycerols: Biodistribution of 1-O-pentylglycerol after intravenous and intracarotid administration in rats. [J] . Erdlenbruch B, Kugler W, Schinkhof C, Journal of drug targeting . 2005,第3期

机译：用烷基甘油打开血脑屏障：大鼠静脉内和颈动脉内给药后1-O-戊基甘油的生物分布。
3. ~(68)Ga-Labeled Gold Glyconanoparticles for Exploring Blood-Brain Barrier Permeability: Preparation, Biodistribution Studies, and Improved Brain Uptake via Neuropeptide Conjugation [J] . Jens Frigell, Isabel Garcia, Vanessa Gomez-Vallejo, Journal of the American Chemical Society . 2014,第1期

机译：〜（68）Ga标记的金糖醇纳米颗粒，用于探索血脑屏障通透性：制备，生物分布研究和通过神经肽结合改善脑摄取
4. Biodistribution and Toxicity Study of Titanium Dioxide Nanoparticles of Different Sizes after Intravenous Injection in Mice [C] . Jie Fang, Lulu Yuan, Chenjie Yao International Conference on Applied Sciences, Engineering and Technology . 2014

机译：小鼠静脉注射后不同尺寸二氧化钛纳米粒子的生物分布和毒性研究
5. Development and application of an in vitro blood-brain barrier model to investigate intravenous immunoglobulin therapy for Alzheimer's disease. [D] . Wuest, Diane Marie. 2014

机译：开发和应用体外血脑屏障模型研究阿尔茨海默氏病的静脉免疫球蛋白治疗。
6. Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in rat [O] . Clémence Disdier, Jérôme Devoy, Anne Cosnefroy, 2015

机译：静脉注射二氧化钛纳米颗粒的组织生物分布显示大鼠血脑屏障清除和脑部炎症
7. Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in rat [O] . Disdier, Clémence, Devoy, Jérôme, Cosnefroy, Anne, 2015

机译：静脉注射二氧化钛纳米颗粒的组织生物分布显示大鼠血脑屏障清除和脑部炎症

Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in rat

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