The evaluation of mean platelet volume levels in patients with primary and secondary Raynaud’s Phenomenon

摘要

Background?—?Mean?platelet?volume?(MPV)?is?an?indicator?of?platelet?activation.?The?pathophysiology?of?the?primary?and?secondary?Raynaud’s?Phenomenon?(RP)?have?not?been?completely?established.?The?aim?of?this?study?was?to?investigate?the?relationship?between?MPV?and?RP.?Materials?and?Methods?—?Our?study?was?a?prospective?randomized?study?carried?out?from?January?2011?to?March?2012.?The?study?group?consisted?of?39?patients:?27?(70%)?patients?having?primary,?12?(30%)?patients?having?secondary?RP.?An?age‐,?gender‐,?and?body?mass?index‐matched?control?group?consisted?of?40?healthy?participants.?We?compared?the?MPV?in?patients?with?RP?and?control?participants?statistically.?Results?—?MPV?of?RP?group?was?8.79±1.37?femtoliter?(fL)?while?MPV?of?control?group?was?8.39±1.36?fL.?Comparison?of?MPV?of?RP?group?and?control?group?showed?no?difference?(p=0.274).?The?mean?of?MPV?was?significantly?higher?among?patients?with?secondary?RP?(9.76±1.68?fl)?when?compared?with?patients?with?primary?RP?(8.37±0.96?fl)?(p=0.018).?Conclusion?—?The?results?of?our?study?suggest?that?MPV?may?be?used?as?a?marker?in?secondary?RP.