Size separation of ultrafine PEG-coated polycaprolactone nanoparticle and morphological studies by AFM

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Size separation of ultrafine PEG-coated polycaprolactone nanoparticle and morphological studies by AFM

机译：超细PEG包覆的聚己内酯纳米粒子的尺寸分离和AFM的形态研究

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Novelultrafinepolycaprolactonenanoparticles(PCLNPs)werepreparedusingpoly(ethyleneglycol)2000-distearylphosphoethanolamine(PEGPE)astheoilyphaseemulsifierintheemulsionprocess,resultinginPEG-coatedPCLNPs(PEGPE-PCL),whichcouldbereducedandconfinedinsizetobelow50nm.SizeseparationofPEG-coatedpolymerNPsremainsignificantchallengesinthepreparationforfundamentalstudiesandapplications.WeusedagelfiltrationchromatographymethodfortherapidsizeseparationofPEGPE-PCLandstudiedthephysicochemicalcharacteristics.Themorphologyofthecore-shellPEGPE-PCLonamicasurfacefollowedbyNPconcentrationwasobservedbyatomicforcemicroscopy(AFM).ItisimportanttoseparatesizeanddefinePEGPE-PCLstructureforfurtherpotentialindrugdeliveryapplication.

机译：Novelultrafinepolycaprolactonenanoparticles（PCLNPs）werepreparedusingpoly（乙二醇）2000-distearylphosphoethanolamine（PEGPE）astheoilyphaseemulsifierintheemulsionprocess，resultinginPEG-coatedPCLNPs（PEGPE-PCL），whichcouldbereducedandconfinedinsizetobelow50nm.SizeseparationofPEG-coatedpolymerNPsremainsignificantchallengesinthepreparationforfundamentalstudiesandapplications.WeusedagelfiltrationchromatographymethodfortherapidsizeseparationofPEGPE-PCLandstudiedthephysicochemicalcharacteristics.Themorphologyofthecore-shellPEGPE-PCLonamicasurfacefollowedbyNPconcentrationwasobservedbyatomicforcemicroscopy（AFM）.ItisimportanttoseparatesizeanddefinePEGPE-PCLstructureforfurtherpotentialindrugdeliveryapplication。

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《Optoelectronics and Advanced Materials-Rapid Communications 》 |2011年第2011期| 共页
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Size separation of ultrafine PEG-coated polycaprolactone nanoparticle and morphological studies by AFM

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