Approximately a century ago, in 1916, the term ‘hydrotropy’ was coined by the scientist Carl A. Neuberg to address anionic organic salts which considerably augmented the aqueous solubility of poorly soluble solutes. Currently hydrotropic solutions possess high industrial demand due to their unique features such as easy availability, good recovery, absence of fire hazards, higher separation factors without any solutes emulsification problem and eco-friendly nature. The present review takes the readers through a concise overview, geometrical features of hydrotropic agents, hypothetical mechanisms and their different advances toward drug delivery. Moreover, this review would provide an insight of the future perspectives concerned with the drug delivery and hydrotropism.
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机译：大约一个世纪前的1916年，“亲水性”一词是由科学家卡尔·A·纽伯格（Carl A. Neuberg）提出的，用于处理阴离子有机盐，该盐大大提高了难溶性溶质的水溶性。当前的水溶解决方案由于其独特的特性而具有很高的工业需求，例如易获得性，良好的回收率，无火灾隐患，更高的分离系数，没有任何溶质乳化问题和生态友好性质。本综述通过简要概述，水溶助长剂的几何特征，假设机理及其在药物输送方面的不同进展为读者提供帮助。此外，本综述将提供有关药物输送和亲水性的未来观点的见解。
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