Morphological study of PathologicalLesions seen in Pleural Biopsies

摘要

Objective: To determine the frequency and types of different pathological lesions seen in pleural biopsies in our patients. Methodology: This is a prospective study carried out in the Department of Pathology, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi. A total of 155 pleural biopsies over a period from 01st January 2007 to 30th June 2008 were reviewed. Haemotoxylin and Eosin (H and E) stained slides were examined to determine the various non- neoplastic and neoplastic lesions. Special stains were performed whenever required. Results: Out of 155 cases of pleural biopsies, 110 cases were diagnosed as non-neoplastic lesions and 29 as neoplastic lesions. The remaining 16 cases were found inconclusive. The non-neoplastic lesions included chronic granulomatous inflammation consistent with tuberculosis 47 cases, chronic non-specific inflammation 42 cases and empyema 21 cases. Chronic granulomatous inflammation consistent with tuberculosis was found to be commonest non-neoplastic lesion with male predominance and maximum number of cases was seen in 2nd decade of life. Neoplastic lesions included adenocarcinoma 26 cases followed by undifferentiated small cell carcinoma, squamous cell carcinoma and malignant lymphoma each comprising single case. Adenocarcinoma was found to be commonest neoplastic lesion with slight female predominance and maximum number of cases was seen in 5th decade of life. Conclusion: The commonest non-neoplastic pleural biopsy lesion was found to be tuberculosis and the commonest neoplastic lesion was adenocarcinoma in pleural biopsy.