Synthesis and Crystal Structure of 3-{4-[(4-(2-Oxo-2,3-dihydro-1H-benzimidazol- 1-yl)piperidin-1-yl)benzyl]}-2-phenylindole

摘要

The X-ray crystal structure of 3-{4-[(4-(2-oxo-2,3-dihydro-1H-benzimidazol- 1-yl)piperidin-1-yl)benzyl]}-2-phenylindole, a compound that showed high cytotoxic potential against various leukemia cell lines, was established. The 3D spatial determination confirmed the structure in the solid state. It crystallizes in the triclinic space group P-1 with cell parameters a=9.572(7) Å, b=11.091(2) Å, c=15.976(4) Å, α=92.53(2), β=105.45(3), γ=94.65(3), V=1625.6(13) Å3 and Z=2. The crystal structure was refined to final values of R1=0.0638 and wR2=0.1800. The crystal packing is controlled by intermolecular hydrogen bonding and C-H e??? interactions. In addition, these new data could be further used to clarify the mechanism of action, implicating the antiproliferative effect of this new synthetic indole derivative on human leukemic cells.