Until the end of the 19th Century the possibilities of betterment/melioration with mental diseases were limited and not encouraging. Therapeutic nihilism infiltrated professionals and population. Development of biological therapies in the first half of the 20th Century apart from modifying the hospitaler conditions of patients and attending personnel caused major changes in the prognosis/prediction of some pathologies and the life quality of patients, who could leave the Madhouse. While Malariotherapy and Penicilin ended with Neurolues, the insulinic coma and the electroshock drastically modified the state picture of many schizophrenic and maniatic-depressive patients, although the prognosis/prediction did not vary. Finally, introduction of phychotropic drugs in the second half of the 20th Century allowed amelioration of. Performances.
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