Hematological Significance of Vitamin A, C and E Bi-combination in Pregnancy

摘要

The present study evaluates the correlation between antioxidant vitamins A, C and E bi-combinations and basic hematological parameters in pregnancy. 70 adult female Wister rats weighing between 250- 300g were procured and grouped into 2 control groups treated with distilled H₂O and vehicle tween-80 respectively and three cohorts (I, II and III) with four sub-groups (n = 5). After mating with male Wister rats, pregnancy was confirmed on the 6^th day. Administration of test agents began on the 7^th day. Cohort group I received a combination of vitamin A and C, group II; vitamin A and E and group III; vitamin C and E respectively at four different doses for 11 days. Blood samples were collected 24hrs after completion of treatment and analyzed for Hemoglobin concentration (Hb), white blood cell (WBC) and differential count. Results revealed a significant increase (p0.05) in Hemoglobin concentration in the vitamin A, C and E bi- combination treated groups. This increase was dose dependent. WBC count was significantly lower (p0.05) in experimental groups as compared to the control ( 8300.00 ± 836.66/mm³) . However, increase in dose brought about increase in WBC count in the experimental groups. Polymorph and lymphocyte count presented mixed results compared to control values following alteration in dosage. Antioxidant vitamins A, C and E bi-combinations posses synergetic potentials and appear promising in pregnancy.