Antiplatelet Therapy in the Perioperative Period (Systematic review)

摘要

Objectives : The goal of our work is to discuss different strategies for preoperative management of antiplatelet therapy and the new anti-platelets drugs types. Background: cardiovascular events represent the major cause of morbidity and mortality. A key role in the pathogenesis of these events is played by platelets. The activated platelet plays not only an important role in the initiation and progression of atherosclerotic disease ⁽¹⁾. Data sources : Medline, articles in Medscape, Science Direct, and PubMed were searched. The search was performed on January 2016 and included all articles with no language restriction. Study selection : The initial search presented 98 articles. The articles stu?ie? antiplatelet therapy in the periоperative periоd. Data extraction : Data from each study were independently abstracted to capture information on study characteristics and interventions. Data synthesis: Significant data were collected . Thus, a structured review was performed. Finding: Antiplatelet agents represent a particular challenge for the anaesthesiologist when regional anaesthetic techniques are considered. New antiplatelet agents have been developed for patients at high risk of thrombosis, their benefits in terms of mortality and major cardiovascular events have been demonstrated. Conclusion: Platelets are essential for primary hemostasis and repair of the endothelium, but they also play a key role in the development of acute coronary syndromes and contribute to cerebrovascular events. Several antiplatelet drugs are available for use in clinical practice and several antiplatelet are under investigation. Antiplatelet and anticoagulants are be useful in the treatment and prophylaxis of arterial thrombotic conditions.