Morphological and immuno-clinical researches during the first half of the 20th century in Cluj, Romania. Overview of the experiments done by Iuliu Moldovan

摘要

During the second half of the 19th century and the whole 20th century, numerous studies concerning the immune system were carried out using different methods of approach. In time, many methods were forgotten, because they were overwhelmed by more modern techniques. The aim of our paper is to present the researches done by the Romanian physician Professor Iuliu Moldovan (1882-1966) regarding one of the defense mechanisms of the human body, having the old name of reticuloendothelial system. Our paper is focused on his experiments done with Reticulin-M. He obtained this substance in 1923, by blocking the reticuloendothelial system of different animals with China ink. Moldovan considered Reticulin-M as a hormone produced by the reticuloendothelial cells. In our paper are also mentioned some important therapeutic effects of this substance on human patients having various diseases.