Mucocutaneous mycoses in acquired immune deficiency syndrome (AIDS) patients hospitalised in a tertiary healthcare centre in the state of Amazonas-Brazil

摘要

Several studies have been performed in which the severity ofhuman immunodeficiency virus(HIV)infection is correlated with skin manifestations. The state of Amazonas-Brazil has a high incidence of HIV infection (2008, 26/100.000 hab), and this state is located in the tropics, a climate that promotes the development of mycoses; however, few studies have been published in the literature that discuss the prevalence of superficial mucocutaneous fungal infections inacquired immune deficiency syndrome(AIDS) patients from this region. The objective of this study was to investigate clinical forms and etiologic agents of mucocutaneous mycoses in AIDS patients hospitalised in a tertiary healthcare centre in the state of Amazonas-Brazil. Specifically, the following factors were investigated: a) the frequency of patients with mucocutaneous mycoses, b) the clinical forms and c) the main etiological agents from the mucocutaneous mycoses. One hundred and seventy patientswere submitted to a dermatological examination to search forpredictivemanifestationsof mucocutaneous mycoses.Laboratory tests(micromorphological studies and culturing) were performedon the biological samples. The samples ofskin scrapings, hair andnails andtheoropharyngeal swabswere transportedto themycologylaboratory ofthe FMT-HVD formicromorphologicaltesting(slides,40%KOHandcottonblue) andculture assays. Among the 170 patients, 116 presented clinical signs. Most of the patients were male (68%) between the ages of 31 and 40 years old (60%).Of the137sitessuspected ofmucocutaneous mycoses,only 52were positive according to the laboratory tests.The most important clinical forms of mucocutaneous mycosis were oral candidiasis (58%) and onychomycosis (31%).Candida albicansandTrichophyton rubrumwere the main causes of oral candidiasis and onychomycosis, respectively.