Anti-Obesity Drug Orlistat (Xenical) Is a Novel Antitumor Medication

摘要

Background:Orlistat(Xenical)isanapprovedmedicationfortreatingobesity.Recentstudiessuggestedanewapplicationfororlistatasanantitumoragent.Objectives:Theaimofthisreviewwastodescribetheeffectoforlistatasanantitumoragentongrowthofcancercells.PatientsandMethods:Articleswereidentifiedindata-basessuchasGoogleScholar,PubMed,ScopusandProquest.Forty-ninearticleswerefoundwithkeywordssuchasorlistatandobesity,orlistatandneoplasm,orlistatandproliferation,antitumorandorlistat,andfattyacidsynthaseandorlistat.Finally25articleswereselectedthatwerepublishedfrom2005untilthepresentandinvestigatedorlistatfunctionsoncancerprogression.Results:Orlistatreducedcancercellsgrowthinvitroandinvivo.Orlistatinhibitedapproximately50%ofproliferationanddecreasedtumorsizecomparedwithcontrolgroups.Itseemsthat,antitumoreffectsoforlistataredosedependentanditshighconcentrationsinhibitproliferationofcellsmorethanlowconcentrations.Conclusions:Orlistatinhibitedfattyacidsynthase,decreasedtumorcellsproliferation,stimulatedtumorcellapoptosisanddecreasedviability.Thusitcanactasananti-tumordrug.Bychangingtheformulationoforalorlistat,wecanproduceanoveldrugwithmorebioavailabilityforabsorptionfromthegastrointestinaltractandmoreanti-tumoractivity.