Ameliorative Role of Jania Rubens Alga Against Toxicity of Heavy Metal Polluted Water in Male Rats

摘要

Elimination of heavy metals from contaminated water is a significant issue. Algae can be used as the detoxifying agent of these metals. This study was achieved to assess the efficacy of red marine alga (Jania Rubens) opposed to the initial modifications that may be concerning the toxicity of heavy metal-polluted water on male rats. 45 male Wistar rats were separated into 3 groups (15 rat/group): Group I (control); Group II (Heavy metal group) and Group III (Treated group). There were significant increases in the levels of SGPT, SGOT, ALP, creatinine, urea, UA, malondialdehyde (MDA), glutathione peroxidase (GPx), protein carbonyl (PC) and significant decrease of body weights& levels of blood hemoglobin, total protein, albumin, catalase, SOD, and GSH in the heavy metal group in comparison with control. Meanwhile, the administration of treated water to rats restores all parameters to normal level in the treated group. Highly significant increase in Metallothionein (MT) levels in hepatic and renal tissue of heavy metal group compared to control, that restored to normal in the treated group. Also, Ni, Cd and Pb metals accumulated in liver, kidney and brain tissues were measured in all studied groups. Our results suggested the ameliorative effect of red marine algae treated water opposed to the toxicity of heavy metals in liver, kidney and brain tissues.