Complex Behaviour of Bile Salts at Various Temperatures Under the Influence of Antidepressant Drug (Imipramine) in Aqueous Solution

摘要

The present method was based on the effect of bile salt (Sodium cholate and Sodium deoxy cholate) on the dissolution of Antidepressant drug like Imipramine. Sodium cholate and Sodium deoxycholate is a type of anionic surfactants form mixed micelle with Imipramine and influence its rate of dissolution. The micellization behavior of binary anionic bile salt surfactant mixtures was investigated by conductivity method and various thermodynamical parameters are calculated. The results of the study have been analyzed by using Clint's, Rubingh's, and Motomura's theories for mixed binary systems.