Design and in Vitro Evaluation Studies of Tramadol Hydrochloride Lozenzes for Treatment of Pain in Childreans

摘要

The oral route is the most preferred route of administration of drugs because of low cost of therapy, ease of administration, patient compliance and flexibility in formulation. The illness are associated with fever, head ache and body aches so to cure the above/relief from the above, there was need to adminster the drugs to the individuals but in case of pediatric patients it was difficult to administer the dosage forms like tablets, capsules, etc. In the present investigation an attempt has been made to prepare and evaluate the sugar based medicated tramadol hydrochloride hard lozenzes for pediatrics to overcome the administration. They were prepared by heating and congealing method on laboraty scale with malt syrup as base. All the formulations were subjected to various physico-chemical parameters such as hardness, friability, content uniformity, weight variation, thickness, drug content and in vitro dissolution studies. Drug-excipients compability stuidies were conducted by FT-IR spectroscopy and results revealed that no interactions were found between drug and excipients. The results of in vitro drug release studies showed that formulations F3, F6 and F9 releases the drug 96.72,95.32 and 98.66 percentage at the end of 30 mins. The hard lozenge can provide an attractive alternative formulatin in the treatment of pain in pediatric patiants.