Activation of leptin receptor signaling via tyrosine phosphorylation of Y1077 provides an important link between control of energy homeostasis and the reproductive axis. In this issue, Patterson and colleagues used transgenic technology to assess the physiological role of LepR-b Tyr"1"0"7"7-dependent signaling in vivo, and defined a role for Tyr"1"0"7"7-dependent signaling in the regulation of endocrine function [1].
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