Ovulation induction by metformin among obese versus non-obese women with polycystic ovary syndrome

摘要

Objectives: There is some evidence that the efficacy of metformin as an ovulation stimulation agent depends on the body mass index (BMI) of the treated anovulatory women with polycystic ovary syndrome (PCOS). The aim of this study was to examine the likelihood of successful ovulation among obese (BMI =30kg/m^2) versus non-obese (BMI =3months were included in the study. Almost 60% of the women who were included in the study were obese. The likelihood of ovulation among obese women with PCOS was 77.9% (odds ratio=0.221, 95% CI 0.052-0.947, P=0.042) less than that in their non-obese counterparts. Conclusion: The findings of this study suggest that metformin is more effective as an ovulation stimulation agent when administered to non-obese women with PCOS. Lifestyle modifications such as diet and exercise should be emphasized upon as an integral part of any treatment plan for PCOS.