Purpose To find out the mean corneal spherical aberration and its changes with age in Saudi population. Setting AlHokama Eye Specialist Center, Riyadh, Saudi Arabia. Methods Three hundred (300) eyes of 185 Saudi subjects (97 men and 88 women), whose age ranged from 15 to 85years old, with matched refractive errors, were divided into three groups according to their age, 100 for each. All the subjects were included in measuring the spherical aberration (SA) using pentacam HR (OCULUS, Germany) at the 6-mm optical zone. Results The mean corneal spherical aberration (CSA) of the fourth order (Z 4 0 ) of the whole groups was 0.252±0.1154μm. Patients from 15 to 35years old have root mean square (RMS) of CSA of 0.2068±0.07151μm, 0.2370±0.08023μm was the RMS of CSA of the patients from 35 to 50years old, while those from 50 to 85years old have a CSA-RMS of 0.31511±0.1503μm ( P <0.0001). A positive correlation was found between the spherical aberration (Z 4 0 ) and the progress of age ( r =0.3429, P <0.0001). The high order aberration (HOA) presented 28.1% of the total corneal aberrations. While the fourth order corneal spherical aberration constituted 57% of the HOA and 16% of the total aberration. The pupil diameter shows a negative correlation with the increase in age ( P =0.0012). Conclusion Our results showed a CSA (Z 4 0 ) that is varied among the population, comparable to other studies, and significantly correlates to the progress of age.
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