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首页> 外文期刊>Saudi Journal of Anaesthesia >Randomized comparison between dexmedetomidine and midazolam for prevention of emergence agitation after nasal surgeries
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Randomized comparison between dexmedetomidine and midazolam for prevention of emergence agitation after nasal surgeries

机译:右美托咪定和咪达唑仑预防鼻腔手术后出现躁动的随机比较

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Background: Emergence agitation (EA) in nasal surgeries is seen in around 22% of patients, which can go to dangerous levels. Dexmedetomidine is effective in prevention of EA in such patients. Midazolam given as premedication fails to prevent EA due to its short half-life. In this study, we compared efficacy of dexmedetomidine and midazolam by intravenous infusion for prevention of EA in adult nasal surgeries. Materials and Methods: Seventy patients belonging to American society of anesthesiologist Status I and II, between 18 and 60 years of age posted for elective nasal surgeries were randomly divided into two groups. Group D received intravenous dexmedetomidine 0.5 mcg/kg over 15 min followed by 0.1 mcg/kg/h. Group M received intravenous midazolam 0.02 mg/kg over 15 min followed by 0.02 mg/kg/h. EA scores, emergence times, and hemodynamic parameters were monitored and compared between the groups. Statistical analysis was done by independent t -test, Mann–Whitney U-test, and Chi-square test as applicable. Results: Incidence of EA was comparable between the groups ( P = 0.23). Two patients in midazolam group developed dangerous agitation while none in dexmedetomidine group. Patients in midazolam group (12.4%) were agitated even in postoperative period, which was not seen with dexmedetomidine group. Hypotension and bradycardia were seen more in dexmedetomidine group. Conclusion: Efficacy of midazolam when given as an intravenous infusion is comparable to dexmedetomidine in prevention of EA in nasal surgeries.
机译:背景:大约有22%的患者出现鼻腔手术中的急躁情绪(EA),可能达到危险水平。右美托咪定可有效预防此类患者的EA。咪达唑仑因半衰期短而无法预防EA。在这项研究中,我们比较了静脉滴注右美托咪定和咪达唑仑在成人鼻腔手术中预防EA的功效。资料和方法:年龄为18至60岁的美国麻醉医师协会状态I和II的70例患者接受了选择性鼻腔手术,被随机分为两组。 D组在15分钟内接受0.5 mcg / kg的静脉右美托咪定,随后接受0.1 mcg / kg / h。 M组在15分钟内接受0.02 mg / kg的咪达唑仑静脉注射,然后接受0.02 mg / kg / h。监测并比较各组的EA评分,出现时间和血液动力学参数。通过独立的t检验,Mann-Whitney U检验和卡方检验进行统计分析。结果:各组间EA的发生率相当(P = 0.23)。咪达唑仑组有2例患者出现危险的躁动,而右美托咪定组无1例。咪达唑仑组(12.4%)的患者甚至在术后都处于躁动状态,右美托咪定组未见到。右美托咪定组低血压和心动过缓多见。结论:静脉输注咪达唑仑在鼻腔手术中预防EA的功效与右美托咪定相当。

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