Effects of medication adherence on hospitalizations and healthcare costs in patients with schizophrenia in Thailand:

摘要

Background:This study was conducted to determine the impacts of medication adherence on hospitalization and direct healthcare cost in patients with schizophrenia in Thailand.Methods:A retrospective study was undertaken. Patients with schizophrenia aged 18–65?years who visited a University hospital and received antipsychotics from April 2011 to October 2011 were included. Propensity score–adjusted logistic regression was used to determine the impacts of medication adherence on schizophrenia-related and all-cause hospitalizations.Results:A total of 582 patients were included. Three out of 224 patients (1.3%) were hospitalized with schizophrenia in optimal adherence group, while 10 of 140 (7.1%) were hospitalized in under-adherence group, and 7 of 218 (3.2%) were hospitalized in over-adherence group. Based on propensity score–adjusted multivariate logistic regression, the adjusted odds ratio was 5.86 (95% confidence interval?=?1.53–22.50) for schizophrenia-related hospitalization and 8.04 (95% confidence int...