Superior memory performance in healthy individuals with subclinical psychotic symptoms but without genetic load for schizophrenia

摘要

Cognitive deficits are a hallmark core feature of schizophrenia and play a predominant role in determining the functional capacity of an individual (Mohamed et al., 2008; Nuechterlein et al., 2012; Green et al., 2000; Kumar et al., 2016). Cognitive deficits have been reported throughout the psychosis continuum and are seen in unaffected siblings and family members of patients with schizophrenia (Snitz et al., 2006; Sitskoorn et al., 2004; Seidman et al., 2007), individuals with psychosis risk syndrome (Fusar-Poli et al., 2012; Yung et al., 2003) and individuals with subclinical psychotic symptoms with genetic predisposition who are at higher risk of conversion to schizophrenia (Trotman et al., 2006; Walder et al., 2008; Daly et al., 2012; Fusar-Poli et al., 2012; Yung et al., 2003).