Combined treatment with minodronate and vitamin C increases bone mineral density and strength in vitamin C-deficient rats

摘要

ObjectivesReduced bone quality caused by vitamin C deficiency in older persons may lead to incidental fragility fractures during bisphosphonate treatment, although bisphosphonate increases bone mineral density (BMD). This study aimed to evaluate the effects of minodronate and ascorbic acid (Aa) on BMD, bone quality, and bone strength in Aa-deficient osteogenic disorder Shionogi (ODS) rats.MethodsSix-month-old ODS rats were divided into four groups (n?=?20 per group): (1) Aa supplementation (Aa+); (2) Aa-deficient (Aa?); (3) Aa supplementation and minodronate administration (Aa+?+?Mino); and (4) Aa-deficient and minodronate administration (Aa??+?Mino). BMD, bone strength, bone histomorphometry, and bone quality determined using Fourier transform infrared spectroscopy imaging (FTIRI) were evaluated after 4 and 8 weeks.ResultsBMD was significantly higher in the Aa+?+?Mino group than in the Aa?group (p?