Synthesis, Structural Elucidation of Novel Thieno [2,3-d] Pyrimidine CoreUnit Containing 1,2,4-Triazoles and Thiophenes as Potent AntimicrobialActivity

摘要

Several new thieno[2,3-d] Pyrimidine derivatives 3-Substituted phenyl-5-(thiophen-2-yl) thieno[3,2-e] [1,2,4] triazolo[4,3-c] pyrimidine 7(a-j), were synthesized starting from thieno[2,3-d] pyrimidine-2,4-diol (1). The characterization of the newly synthesized compounds was established by IR, 1H NMR, 13C NMR and Mass Spectral analysis. The final compounds were screened for their anti-bacterial activity against Bacillus subtilis and Staphylocouccus aureus from Gram positive group of bacteria and Escherichia coli and Klebsiella pneumonia from Gram negative group of bacteria and antifungal activity against Candida albicans and Aspergillus flavus. Antibacterial and anti-fungal activities were Evaluated and compared with the standard drugs. From anti-bacterial and anti-fungal activity screening results, it has been observed that compounds 8i, 8j, 8e possess good activity.