Synthesis and Biological Evaluation of 4-(3-Hydroxy-benzofuran-2-yl)coumarins

摘要

Various 4-bromomethylcoumarins (1a-k) were reacted with methyl salicylate to yield 2-(2-oxo-2H-chromen-4-ylmethoxy)-benzoic acid methyl esters (2a-k). Formations of (3a-k) were achieved by using DBU under microwave irradiation. Structures of all the compounds were established on the basis of their spectral data. All the compounds were testedin vitrofor their antimicrobial activity and cell cytotoxicity. All the tested compounds (2b-k) and (3a-k) were shown to be better activity againstStaphylococcus aureusthan the standardCiprofloxacin. The compound (3k) (R = 6-OMe) was found to be more potent cytotoxic than the standard5-fluorouracil.