Use Of Amorolfine In Candida- Associated Denture Stomatitis

摘要

Denture stomatitis(DS) is an inflammatory lesion, in which there is redness of the oral mucosa underneatha removable denture. Although Candidaalbicans is a component of normal microbial flora,localand systemic factors can cause opportunistic infections.Poorly fitting or unhygienic dentures leads to the presence of yeasts attached to it., and cause inflammation.Treatment procedures include correction of ill-fittingdentures,plaque control, and topical and systemic antifungal therapy. Nystatin and Amphoteresin B are used topically as suspension. Since candidiasisis highly resistant toantifungal agents, systemic usage of ketoconazole,fluconazole or itraconazole are necessary. But the systemic use of these drugs can cause side effects like liver toxicity, druginteractions etc. Lucio; Lorengo etal had conducted a study of the efficacy of amorolfine antifungal varnish, by local application, and found that it suppresses the nystatin resistant Candida associated denture stomatitis.