The peripheral giant cell granuloma (PGCG) is a benign inflammatory hyperplastic type of lesion of unknown etiology occurring in gingiva or alveolar ridge. It normally presents as a soft tissue purplish-red nodule consisting of multinucleated giant cells in a background of mononuclear stromal cells and extravasated red blood cells. A 75 years old male patient reported with a chief complaint of pain and swelling in lower right back region of mouth. On intra-oral examination the swelling was red, firm and sessile with smooth surface texture. The orthopantomogram (OPG) revealed a well-demarcated radiolucency extending from distal aspect of mandibular canine to mesial aspect of mandibular first molar. The cone beam computed tomography also showed the features suggestive of soft tissue lesion causing cupping resorption of mandible. Excisional biopsy was performed under local anaesthesia and tissue was examined histopathologically. The lesion was diagnosed as PGCG after thorough clinical, radiologic and histopathologic examination.
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