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外文期刊>Oftal mokhirurgiya
>Эффективность интравитреального введения Луцентиса в лечении диффузного диабетического макулярного отека на фоне панретинальной лазеркоагуляции при пролиферативной диабетической ретинопатии
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Эффективность интравитреального введения Луцентиса в лечении диффузного диабетического макулярного отека на фоне панретинальной лазеркоагуляции при пролиферативной диабетической ретинопатии
Purpose. To evaluate the efficacy of intravitreal injection?of Lucentis in the treatment of diffuse diabetic macular edema?(DME) associated with pan-retinal photocoagulation in the proliferative?diabetic retinopathy (DR). Material and methods. A retrospective study (58 eyes) with?a high diffuse DME and proliferative DR was performed in 46 patients?with insulin-dependent diabetes mellitus aged 45-73 years?(mean age: 59.2±0.9 years). All participants underwent i ntravitreal?injection (IVI) of Lucentis pars plana. The pan-retinal photocoagulation?(PRPC) stage was performed 2 weeks after each Lucentis?IVI. The main criteria were the dynamics of best corrected?visual acuity (BCVA), the OCT parameters – in the central retinal?thickness (1mm) area and volume of the macula. The treatment?efficacy was assessed one month after the final PRPC stage. Results and discussion . At the end of treatment an increase?in the average BCVA values from 0.32 to 0.45, a decrease in retinal?thickness in fovea zone – from 506.9mm to 394.6mm, in the?volume of macula from 12.9 to 11.6mm3 were noted. Stabilization?or an increase in initial visual acuity was observed in 83.4%.?The initial thickness of the retina in the region of 1mm was reduced?from 506.9mm to 394.6mm, i.e. decreased by an average?of 22%. The stabilization of visual functions was achieved more?than in 80% of cases one month after the combi ned treatment. Conclusions . The performed retrospective study showed?an efficacy of intravitreal injection of Lucentis to stabilize visual?functions, to reduce the height of macular edema during the?pan-retinal photocoagulation in patients with proliferative diabetic?retinopathy.
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机译:目的。为了评估玻璃体腔注射Lucentis在增生性糖尿病性视网膜病变(DR)中与泛视网膜光凝相关的弥漫性糖尿病性黄斑水肿(DME)的治疗效果。材料与方法。一项回顾性研究(58眼)具有高弥散DME和增生性DR在46例45-73岁(平均年龄:59.2±0.9岁)的胰岛素依赖型糖尿病患者中进行。所有参与者均接受了Lucentis pars Plana的玻璃体内注射(IVI)。每个Lucentis IVI后2周进行全视网膜光凝(PRPC)阶段。主要标准是最佳矫正视力(BCVA)的动力学,OCT参数-视网膜中央厚度(1mm)区域和黄斑体积。在最后的PRPC阶段一个月后评估治疗效果。结果和讨论 。在治疗结束时,平均BCVA值从0.32增加到0.45,黄斑中心区的视网膜厚度从506.9mm减少到394.6mm,黄斑体积从12.9mm减少到11.6mm3。观察到稳定或初始视力增加了83.4%。1mm区域的视网膜初始厚度从506.9mm减少到394.6mm,即平均减少了22%。联合治疗一个月后,视觉功能的稳定达到了80%以上。结论。进行的回顾性研究表明,玻璃体腔注射Lucentis可以稳定增生性糖尿病视网膜病变患者在全视网膜光凝过程中稳定视功能,降低黄斑水肿高度。
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