Natural polyphenols improve the dislipidemy and eye complications in the experimental diabetes mellitus

摘要

The benefits of the polyphenols extracted from the seeds of black grapes, have been shown by using as experimental model the streptozotocin-induced diabetes mellitus on the Wistar rats. The streptozotocin was administered in a single dose of 60 mg/Kg body mass, intraperitoneal. The vegetal polyphenols were administered under the form of water solution, in a dose of 0,028 g/KG body mass, p.o. (through tube feeding), every two days, for a period of 16 weeks (3 weeks before the streptozotocin induction and 13 weeks after). The results obtained point out a significant improvement (p 0.05). All the animals suffering from DM experienced various degrees of retinal detachment. Polyphenols intake by diabetic animals resulted into a low retina disease rate. They experienced only random and uneven retina detachment. Another complication that occurred in all diabetic rats, even in those that received polyphenols treatment, was diabetic cataract. Microscopic investigations reveal a crystalline cortex full of vacuoles or a homogeneous substance with residues of pathological crystalline fibres. Diabetic animals that benefited from polyphenols protection experience only scarce and isolated soft exudates.